Medicine

Progressing ASO treatments from development to implementation

.Competing passions.R.S., M.S., H.G. and A.A.R. are coordinators of the 1M1M initiative. H.G. as well as A.A.R. are board of directors members and also R.S., M.S. and also A.A.R. are actually participants of the clinical consultatory board of N1C. A.A.R. makes known job through LUMC, which possesses licenses on exon-skipping technology, some of which has actually been accredited to BioMarin as well as consequently sublicensed to Sarepta. As co-inventor of several of these licenses, A.A.R. was entitled to a portion of aristocracies. A.A.R. even further makes known working as impromptu professional for PTC Rehabs, Sarepta Therapeutics, Regenxbio, Dyne Therapies, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. Before 5 years, A.A.R. additionally executed ad hoc consulting with for Alpha Anomeric. A.A.R. likewise discloses membership of the scientific advisory boards of Eisai, Hybridize Therapeutics, Muteness Therapies, Sarepta Therapies, Sapreme and Mitorx. Over the last 5 years, A.A.R. was also a medical board of advisers participant for ProQR. Reimbursement for A.A.R. u00e2 s consulting as well as suggesting tasks is paid out to LUMC. Over the last 5 years, LUMC also got speaker honoraria from PTC Therapies, Alnylam Netherlands, Italfarmaco and Pfizer and also funding for deal study from Sapreme, Eisai, Galapagos, Synaffix as well as Alpha Anomeric. Project backing is actually gotten coming from Sarepta Rehabs and also Entrada via unrestricted grants. H.G. has nothing to disclose in relation to the subject matters covered in this particular manuscript. In the past 5 years, he has additionally obtained consultancy gratuity coming from UCB. M.S. acquired working as a consultant honoraria from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly as well as Solaxa previously 5 years, all unassociated to the here and now document. R.S. has nothing to divulge relative to the topics dealt with within this composition. She has actually acquired audio speaker and/or working as a consultant honoraria or financing payments coming from Abbvie, Bial, STADA and Everpharma over the last 5 years.